Fittingly for the final outing at Croke Park, the match will mark a 70th Ireland cap for Paul O'Connell who led Ireland out for the first rugby international there against France in 2007.
Centre Gordon D'Arcy has been included in the starting line-up as he continues to recover from the deep bruising to his leg, sustained against Wales. He will be monitored in training and a final decision will be made on Friday.
Should D'Arcy not be passed fit, his place at inside centre will be taken by Paddy Wallace.
14 - Tommy Bowe (Ospreys)
13 - Brian O'Driscoll (UCD/Leinster) (capt)
12 - Gordon D'Arcy (Lansdowne/Leinster)
11 - Keith Earls (Young Munster/Munster)
10 - Jonathan Sexton (St. Mary's College/Leinster)
9 - Tomas O'Leary (Dolphin/Munster)
1 - Cian Healy (Clontarf/Leinster)
2 - Rory Best (Banbridge/Ulster)
3 - John Hayes (Bruff/Munster)
4 - Donncha O'Callaghan (Cork Constitution/Munster)
5 - Paul O'Connell (Young Munster/Munster)
6 - Stephen Ferris (Dungannon/Ulster)
7 - David Wallace (Garryowen/Munster)
8 - Jamie Heaslip (Naas/Leinster)
17 - Tony Buckley (Shannon/Munster)
18 - Leo Cullen (Blackrock College/Leinster)
19 - Shane Jennings (St. Mary's College/Leinster)
20 - Eoin Reddan (Lansdowne/Leinster)
21 - Ronan O'Gara (Cork Constitution/Munster)
22 - Rob Kearney (UCD/Leinster)