Cian Healy and Mike Ross come into the starting front row alongside John Fogarty, with Shane Jennings continuing in the back row alongside fellow Ireland internationals Kevin McLaughlin and Jamie Heaslip.
Shaun Berne will partner Eoin Reddan at half-back, starting in place of the injured Jonathan Sexton, while Gordon D'Arcy will be joined at centre by Bank of Ireland Player of the Month Fergus McFadden who will make his 15th appearance of the season.
Girvan Dempsey starts at full-back, replacing the injured Rob Kearney, in a back-three which also includes Shane Horgan and Isa Nacewa. The replacements bench will be confirmed closer to kick-off.
LEINSTER (v Ospreys): Girvan Dempsey; Shane Horgan, Fergus McFadden, Gordon D'Arcy, Isa Nacewa; Shaun Berne, Eoin Reddan; Cian Healy, John Fogarty, Mike Ross, Leo Cullen (capt), Nathan Hines, Kevin McLaughlin, Shane Jennings, Jamie Heaslip.
Replacements (from): Richardt Strauss, Stan Wright, Malcolm O'Kelly, Stephen Keogh, Paul O'Donohoe, Eoin O'Malley, Andrew Conway, Simon Keogh.