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Team News: Friday will see Munster hooker Jerry Flannery return to competitive action for the first time since he picked up a six-week suspension against France in the RBS 6 Nations.
Flannery is one of four Ireland internationals making a return to Magners League action for this top of the table clash with Leinster, Tomas O'Leary, John Hayes and David Wallace being the others.
However, two players named in Munster's extended squad on Tuesday - team captain Paul O'Connell and Keith Earls - have both been forced to withdraw due to groin strains.
In relation to their availability for the Heineken Cup quarter-final against Northampton in a week's time, team manager Shaun Payne said that neither player has been ruled out at this stage.
18 of Friday's matchday 22 were involved when the sides last met at the RDS back in October.
From that game, which Leinster won on a 30-0 scoreline, Denis Leamy and Denis Hurley are now joined on the injury list by O'Connell and Earls.
In the absence of O'Connell, Munster will be captained by out-half Ronan O'Gara who is set to win a 180th cap for his home province.
Meanwhile, Gordon D'Arcy, a try scorer against Munster last October, will start at inside centre and partner Fergus McFadden in the only change in the back-line to the Leinster side that defeated Connacht last weekend.
Rob Kearney continues at full-back with Girvan Dempsey and Isa Nacewa on the wings, while Eoin Reddan will once again combine with Jonathan Sexton at half-back. Injury rules out both Brian O'Driscoll and Shane Horgan.
Jamie Heaslip, back from RBS 6 Nations duty, has also been named in the starting line-up for Friday's interprovincial derby.
The number 8 will slot into a back-row which includes fellow Ireland international Shane Jennings and Scotland's Nathan Hines.
Leo Cullen will captain the current Magners League leaders and starts in the second row alongside Devin Toner, while Cian Healy joins fellow Ireland internationals Bernard Jackman and Malcolm O'Kelly on the bench.
MUNSTER: Paul Warwick; Doug Howlett, Lifeimi Mafi, Jean de Villiers, Ian Dowling; Ronan O'Gara (capt), Tomas O'Leary; Marcus Horan, Jerry Flannery, John Hayes, Donncha O'Callaghan, Mick O'Driscoll, Alan Quinlan, Niall Ronan, David Wallace.
Replacements: Denis Fogarty, Tony Buckley, Nick Williams, James Coughlan, Peter Stringer, Tom Gleeson, Scott Deasy.
LEINSTER: Rob Kearney; Girvan Dempsey, Fergus McFadden, Gordon D'Arcy, Isa Nacewa; Jonathan Sexton, Eoin Reddan; Stan Wright, John Fogarty, CJ van der Linde, Leo Cullen (capt), Devin Toner, Nathan Hines, Shane Jennings, Jamie Heaslip.
Replacements: Bernard Jackman, Cian Healy, Malcolm O'Kelly, Stephen Keogh, Paul O'Donohoe, Shaun Berne, Eoin O'Malley.
Referee: Romain Poite (France)
Assistant Referees: Colin Stanley, Richard Kerr (both Ireland)
Television Match Official: Brian Fitzgerald (Ireland)
Match Odds (Paddy Power): Munster to win: 4/11; Draw: 20/1; Leinster to win: 2/1
Pre-Match Quotes: Leo Cullen (Leinster) - "Training has been a bit disjointed over the last while and it was the same last week with the return of the international players from Ireland camp, so it was hardly ideal preparation from our point of view.
"When you come up against a team like Connacht who are together for longer periods without too much disruption to their personnel, you have to adapt fast and to their credit they looked more cohesive and were unlucky not to come away with something more from the game.
"We had opportunities to win the game, but we got out of jail and the players know that we will have to improve this week because we're coming up against an in-form Munster team who have been steadily improving in recent months.