Saturday's match will see Shane Horgan become the first Leinster player to reach the 75 Heineken Cup appearance landmark and the big winger is named in a back-line which features six Ireland internationals.
Brian O'Driscoll partners Gordon D'Arcy at centre, with Eoin Reddan lining up at half-back alongside the returning Sexton who will be making his 50th appearance for the province.
In the pack, prop Cian Healy, who is also set to chalk up a half-century of Leinster caps, has been named in the front row alongside hooker John Fogarty and Stan Wright, with Leo Cullen leading the side from the second row.
The influential Jennings starts in the back row alongside Kevin McLaughlin and Jamie Heaslip.
South African international CJ van der Linde has recovered from injury to take his place on a strong-looking replacements bench which includes Ireland internationals Girvan Dempsey, Bernard Jackman, Sean O'Brien, Malcolm O'Kelly and Mike Ross.
Ticketmaster will also be selling tickets at the RDS from 3pm on Saturday.
* Staff from Dublin's 98, Newstalk, Spin and Today FM will be collecting in and around the RDS in aid of Concern's Haiti Earthquake Response Appeal on Saturday evening. Please give generously if you can. Concern have staff on the ground in Haiti and are distributing food, water, shelter materials and medical supplies.
LEINSTER (v Brive): Rob Kearney; Shane Horgan, Brian O'Driscoll, Gordon D'Arcy, Isa Nacewa; Jonathan Sexton, Eoin Reddan; Cian Healy, John Fogarty, Stan Wright, Leo Cullen (capt), Nathan Hines, Kevin McLaughlin, Shane Jennings, Jamie Heaslip.
Replacements: Bernard Jackman, Mike Ross, CJ van der Linde, Malcolm O'Kelly, Sean O'Brien, Paul O'Donohoe, Shaun Berne, Girvan Dempsey.