The experienced trio of Orla Brennan, Amy Davis and Sinead Ryan make their first appearances of the 2010 Championship, while Gillian Bourke and Caroline Mahon have been promoted from the replacements bench.
Those five players have over 60 international caps between them and will bring a level of experience to the side as they face a tough French outfit that lost 10-8 to Scotland in their opener.
Brennan and Ryan come into the back row for Carol Staunton and Claire Molloy, while Mahon moves into the second row to replace Kate O'Loughlin.
Bourke starts at hooker with Chris Fanning named among the replacements, and the pacy Davis starts on the right wing with Nora Stapleton reverting to the bench having earned her first cap last Friday.
IRELAND WOMEN'S Team & Replacements (v France Women, RBS Women's 6 Nations Championship, Stade Allés, Blois, Friday, February 12, kick-off 7pm local time/ 6pm Irish time):
15 - Niamh Briggs (Clonmel/Munster)
14 - Amy Davis (Blackrock/Leinster)
13 - Grace Davitt (Blackrock/Leinster)
12 - Shannon Houston (Blackrock/Leinster)
11 - Alison Miller (Portlaoise/Connacht)
10 - Joanne O'Sullivan (Richmond/Exile)
9 - Tania Rosser (Blackrock/Leinster)
1 - Fiona Coghlan (UL Bohemians/Leinster) (capt)
2 - Gillian Bourke (UL Bohemians/Munster)
3 - Emer McManamly (Blackrock/Leinster)
4 - Caroline Mahon (UL Bohemians/Leinster)
5 - Marie Louise Reilly (Navan/Leinster)
6 - Orla Brennan (Blackrock/Leinster)
7 - Sinead Ryan (Navan/Leinster)
8 - Joy Neville (UL Bohemians/Munster)
16 - Chris Fanning (Highfield/Munster)
17 - Lauren Day (Cooke/Ulster)
18 - Kate O'Loughlin (Clonmel/Munster)
19 - Claire Molloy (Bristol/Connacht)
20 - Louise Beamish (UL Bohemians/Munster)
21 - Helen Brosnan (Highfield/Munster)
22 - Nora Stapleton (Old Belvedere/Leinster)