The third player, David Kearney, is named on the left wing and also makes his second Leinster appearance in a back-three which includes Isa Nacewa and Shane Horgan.
In the pack, Devin Toner partners skipper Leo Cullen in second row, with Sean O'Brien coming into the team to start at number 8.
Gordon D'Arcy and Nathan Hines are named on a strong replacements bench which also includes summer signing Eoin Reddan.
Tickets will be available on the day from Ticketmaster outlets on Angelsea Road (opposite the Herbert Park Hotel) and Simmonscourt Road, from 4.30pm until kick-off.
LEINSTER (v Newport Gwent Dragons): Isa Nacewa; Shane Horgan, Fergus McFadden, Shaun Berne, David Kearney; Jonathan Sexton, Chris Keane; Cian Healy, John Fogarty, Mike Ross, Leo Cullen (capt), Devin Toner, Kevin McLaughlin, Shane Jennings, Sean O'Brien.
Replacements: Jason Harris-Wright, Stan Wright, Nathan Hines, Stephen Keogh, Eoin Reddan, Gordon D'Arcy, Simon Keogh.