Fiji coach Glen Ella, whose management team includes former Leinster forwards coach Mike Brewer, has made five changes to the side that lost 23-10 to Scotland at Murrayfield.
The experienced Norman Ligairi returns at full-back, replacing the benched Josh Matavesi, and Nasoni Roko comes in for Napolioni Nalaga on the left wing.
There are three changes up front, with Asaike Tarogi and Viliame Seuseu drafted into the front row, and Apolosi Satala joining his Gloucester team-mate Akapusi Qera in the back row.
Notably, Ulster's popular winger Timoci Nagusa has gained a place on the bench having linked up with the squad in Dublin earlier in the week.
Nagusa has played three times for Fiji, his last appearance coming in June of this year when he scored two tries in the Pacific Nations Cup win over Tonga.
Fiji captain Seremaia Bai, who plays his club rugby for French side Clermont Auvergne, is one of the current players who lined out in the 64-17 defeat to Ireland on their last visit to Dublin in November 2002.
Ligairi, out-half Nicky Little and lock Ifereimi Rawaqa also featured in that game at Lansdowne Road.
Meanwhile, as the second game in the 2009 GUINNESS Series against the flying Fijians looms closer, the last remaining tickets for the first senior international match at the RDS are available for purchase to the general public.
The 18,500-capacity RDS is almost full and fans are encouraged to secure their tickets as soon as possible to avoid missing out on what promises to be an exciting game.
Tickets can be purchased online here, at the SPAR Shop, Main Street, Donnybrook or from the IRFU Offices at 10-12 Lansdowne Road, Ballsbridge on the day of the game between 1pm and 4pm.
Tickets are priced at:
€32 - Anglesea Stand Reserved
€32 - North and South Stand (Unreserved)
€40 - Grandstand Reserved
FIJI TEAM & REPLACEMENTS (v Ireland, GUINNESS Series 2009, The RDS, Saturday, November 21, kick-off 5.15 pm):
15 - Norman Ligairi (Brive)
14 - Vereniki Goneva (Vaturu)
12 - Seremaia Bai (Clermont Auvergne) (capt)
11 - Nasoni Roko (Yokogawa)
10 - Nicky Little (Padova)
9 - Mosese Rauluni (Saracens)
1 - Asaike Tarogi (Suva Highlanders)
2 - Viliame Veikoso (Mavoci)
3 - Viliame Seuseu (Korovuto)
4 - Wame Lewaravu (London Welsh)
5 - Ifereimi Rawaqa (Fighting Bulls)
6 - Apolosi Satala (Gloucester)
7 - Akapusi Qera (Gloucester)
8 - Asaeli Boko (Tau)
16 - Isireli Ledua (FTG)
17 - Graham Dewes (Esher)
18 - Leone Nakarawa (Army)
19 - Samu Bola (Police)
20 - Waisale Vatuvoka (Duavata)
21 - Josh Matavesi (Exeter Chiefs)
22 - Timoci Nagusa (Ulster)