Donnacha Ryan starts at blindside flanker with Ulster's Ed O'Donoghue coming onto the replacements bench for his first involvement in an Irish squad.
Isaac Boss has recovered from illness and is also among the replacements, being preferred to Chris Keane.
The 'A' side will again be captained by Bob Casey, who led them to the Barclays Churchill Cup Plate title last summer.
Supporters who purchased tickets for the Ireland 'A' v England Saxons game may present their ticket for entry to this game which kicks off at 7.35pm at the RDS.
IRELAND 'A' TEAM & REPLACEMENTS (v Scotland 'A' , 'A' International Match, RDS, Friday, February 13, kick-off 7.35pm):
15 - Gavin Duffy (Galwegians - Connacht)
14 - Andrew Trimble (Ballymena - Ulster)
13 - Darren Cave (Belfast Harlequins - Ulster)*
12 - Keith Matthews (Buccaneers - Connacht)*
11 - Mark McCrea (Malone - Ulster)*
10 - Jonathan Sexton (St. Mary's College - Leinster)*
9 - Eoin Reddan (London Wasps)
1 - Cian Healy (Clontarf - Leinster)*
2 - Sean Cronin (Buccaneers - Connacht)*
3 - Mike Ross (Harlequins)*
5 - Ryan Caldwell (Dungannon - Ulster)*
6 - Donnacha Ryan (Shannon - Munster)
7 - Shane Jennings (St. Mary's College - Leinster)
8 - John Muldoon (Galwegians - Connacht)*
16 - John Fogarty (Clontarf - Leinster)*
17 - John Andress (Exeter)*
18 - Ed O'Donoghue (Instonians - Ulster)*
19 - Sean O'Brien (Clontarf - Leinster)*
20 - Isaac Boss (Ballymena - Ulster)
21 - Ian Humphreys (Ballymena - Ulster)*
22 - Barry Murphy (UL Bohemians - Munster)
* denotes uncapped players