Meanwhile, the Ospreys have rested all of their 2009 Lions players, including Ireland winger Tommy Bowe, for their final game of the season.
Head coach Sean Holley has still selected a strong starting line-up, with Wales captain Ryan Jones, free-scoring out-half James Hook and Sonny Parker and Ian Gough included.
It will be a memorable occasion for centre Parker as he makes his 100th appearance for the Ospreys, while winger David Evans is set to make his debut.
This will be Holley's last game in charge of the Welsh region as Scott Johnson is taking over for next season.
MUNSTER: Paul Warwick; Doug Howlett, Keith Earls, Lifeimi Mafi, Ian Dowling; Ronan O'Gara, Peter Stringer; Federico Pucciariello, Denis Fogarty, Tony Buckley, Mick O'Driscoll, Paul O'Connell (capt), Denis Leamy, Niall Ronan, David Wallace.
Replacements: Frankie Sheahan, Dave Ryan, Donncha O'Callaghan, John O'Sullivan, Mike Prendergast, Anthony Horgan, Kieran Lewis.
OSPREYS: Gareth Owen; Ashley Beck, Sonny Parker, Jonathan Spratt, David Evans; James Hook, Jamie Nutbrown; Paul James, Richard Hibbard, Cai Griffiths, Ian Gough, Andy Lloyd, Ryan Jones (capt), Marty Holah, Filo Tiatia.
Replacements: Scott Baldwin, Duncan Jones, Craig Mitchell, Richard Kelly, Steve Tandy, Rhodri Wells, Dan Biggar.
Referee: Peter Allan (Scotland)
Assistant Referees: Alan Rogan, Mark Hermin (both Ireland)
Television Match Official: Dermot Moloney (Ireland)
Match Odds (Paddy Power): Munster to win: 1/16; Draw: 28/1; Ospreys to win: 7/1
Say What: Federico Pucciariello (Munster) - "I had been moving around Europe for 10 years with several different clubs - Narbonne, Gloucester and Bourgoin - and it was difficult for my wife and family, so I knew it would be my last contract.
"I came to Munster from Bourgoin because I saw it as a challenge. Munster already had international props in Marcus (Horan) and John (Hayes). I knew I would have to compete very hard. But that is what I like.
"The last four seasons have flown by very quickly. The time seems to have passed like it was two weeks. I had the option to live in Limerick or Cork. But when I came to Limerick I was taken with how friendly people were. They were chatty and smiling.
"I had never stayed more than three years with any of my previous clubs, but I enjoyed myself so much with Munster that I have been here for four seasons. Being involved with this team has been something very special.
"There have been so many highglights, but winning the Heineken Cup for the first time against Biarritz in 2006 was a terrific occasion. The first time you do something is better than any other time.
"The All Blacks game at Thomond Park was another highlight. I still keep thinking we should have won that match. And winning the Magners League this year was very satisfying too. It is so competitive.
"I was fortunate enough to score seven tries during my time with Munster. Scoring a try gives me a great sensation. It is so hard for a prop to score.