Click here to view the Tier 2 November match list.
The first match kicked off last evening when Americas Rugby Championship winners, the Argentina Jaguars, took on Canada 'A' in Chatham, Ontario.
The Argentinians, who face Churchill Cup champions Ireland 'A' in Tallaght on November 27, scored a 42-16 win over Canada 'A'.
November will also witness the first ever visit of an Argentinean team to Georgia, when, to celebrate the 50th anniversary of the foundation of the Georgia Rugby Union, the Jaguars face the Lelos in Tbilisi on November 13.
IRB Head of Development and Performance Mark Egan said: "This is an unprecedented and exciting November schedule of matches which we intend to replicate on an annual basis as a part of our HP investment strategy.
"The IRB is providing significant funding towards the flights and accommodation costs of the overall programme and we would like to recognise the financial contribution of the SRU, FIR and IRFU in supporting the games which they are hosting.
"The IRB continues to invest over £5.5million annually via a portfolio of regional tournaments such as the European Nations Cup and strategic investment tournaments, including the ANZ Pacific Nations Cup, IRB Nations Cup and the Americas Rugby Championship.
"These tournaments play an essential role in each Union's player development pathway with the ultimate objective of improving competitiveness across all our Strategic Investment Programme Unions.
"However, it is essential that all our High Performance Unions have between seven and 10 Test match level games each year in order to benchmark player and coach development programmes, challenge for IRB World Ranking points and provide a competition environment in which Unions can prepare for RWC 2011 in New Zealand."
Egan added: "The programme also provides for an exciting opportunity for the recently formed Argentina Jaguars to embark on their inaugural tour of Europe following investment from the IRB in the UAR's domestic High Performance structures."
Click here to view the fixtures for Ireland and Ireland 'A' during November.