Jeannette Feighery comes back into the starting line-up on the right wing, in place of injured Grace Davitt.
Shannon Houston has been promoted from the bench to inside centre with Helen Brosnan moving to the replacements.
Notably, Cooke team-mates Lauren Day and Laura Nicholl make their first appearances in a matchday squad in this year's Championship
Coach Hennessy said: "The England game was tough, but we played a great first half and are focusing on that performance.
"While we were obviously disappointed with the end result we took a lot of positives from that game.
"We have a good record against Scotland, but we won't be underestimating them on Friday. We have prepared for a tough physical game and are ready for it.
"We are aware this is a vital game, a win on Friday will automatically qualify us for next year's World Cup and put us in a great position for the final week of the Championship where it will be all to play for."
IRELAND WOMEN'S TEAM & REPLACEMENTS (v Scotland Women, 2009 RBS Women's 6 Nations Championship, Meggetland, Friday, March 13, kick-off 7.30pm):
15 - Niamh Briggs (Clonmel/Munster)
14 - Jeannette Feighery (UL Bohemians/Munster)
13 - Lynne Cantwell (UL Bohemians/Munster)
12 - Shannon Houston (Blackrock/Leinster)
11 - Amy Davis (Blackrock/Ulster)
10 - Joanne O'Sullivan (Richmond/Ulster)
9 - Tania Rosser (Blackrock/Leinster)
2 - Yvonne Nolan (Blackrock/Leinster)
3 - Gillian Bourke (UL Bohemians/Munster)
4 - Caroline Mahon (UL Bohemians/Leinster)
5 - Orla Brennan (Blackrock/Leinster)
6 - Louise Austin (Blackrock/Leinster)
7 - Sinead Ryan (Navan/Leinster)
8 - Joy Neville (UL Bohemians/Munster) (capt)
16 - Jess Limbert (Lichfield/Ulster)
17 - Lauren Day (Cooke/Ulster)
18 - Kate O'Loughlin (Clonmel/Munster)
19 - Debbie Clarke (Blackrock/Leinster)
20 - Louise Beamish (UL Bohemians/Munster)
21 - Laura Nicholl (Cooke/Ulster)
22 - Helen Brosnan (Highfield/Munster)