Notably, in the province's back-line, Ireland 'A' international Felix Jones gets a run at full-back and Ian Dowling replaces Doug Howlett on the left wing.
Saturday's interprovincial is a game that provides Munster with the opportunity to get their Magners League campaign back on track, according to experienced lock Mick O'Driscoll.
"We wouldn't be at all happy with our form in the league. It's something we've spoken about and need to address," he admitted.
"This game provides not only the chance to do that but also gives lads the opportunity to put their hands up (for selection)."
"Not at all. The changes freshen things up and brings a different impetus to the side.
"Connacht have done every bit as well as us in Europe these past weeks, beating Worcester twice, and they'l be full of confidence. So no, we know what we'll be up against. These game are never a 'gimme'. Never easy."
MUNSTER (v Connacht): Felix Jones; Denis Hurley, Tom Gleeson, Jean de Villiers, Ian Dowling; Ronan O'Gara (capt), Peter Stringer; Julien Brugnaut, Damien Varley, Tony Buckley, Mick O'Driscoll, Donnacha Ryan, Billy Holland, Niall Ronan, Nick Williams.
Replacements: Mike Sherry, Wian du Preez, James Coughlan, Tommy O'Donnell, Duncan Williams, Paul Warwick, Scott Deasy.