Jamie Heaslip, who made his 100th appearance for the province in the bonus point win, is one of seven Ireland international forwards in the extended squad.
Young flanker Rhys Ruddock, who made his debut in the recent Magners League game against the Dragons, joins Chris Keane, Simon Keogh, Ronan McCormack and Devin Toner in the 28-man selection which will be reduced on Friday afternoon.
In addition to the usual 'Family Day' activities on matchday at the RDS, there will be a number of themed seasonal events for Leinster's final home game before Christmas.
Alexandra College Choir will be getting supporters in the festive mood around the ground on Saturday in aid of Fr. Peter McVerry's 'Welcome Home' charity. Meanwhile, up and coming band 'Theo and the Red Beats' will also be performing at half-time.
Tickets for Saturday's Heineken Cup game against the Scarlets have now sold out online. There are a small number of tickets still on sale in the Leinster Rugby Store and Spar shop in Donnybrook.
This will be a ticket only match and there will be no tickets on sale at the gate on the day.
LEINSTER (v Scarlets) - Backs (12): Shaun Berne, Gordon D'Arcy, Girvan Dempsey, Shane Horgan, Chris Keane, Rob Kearney, Simon Keogh, Fergus McFadden, Isa Nacewa, Paul O'Donohoe, Brian O'Driscoll, Eoin Reddan.
Forwards (16): Leo Cullen (capt), John Fogarty, Cian Healy, Jamie Heaslip, Nathan Hines, Bernard Jackman, Stephen Keogh, Ronan McCormack, Kevin McLaughlin, Sean O'Brien, Malcolm O'Kelly, Mike Ross, Rhys Ruddock, Devin Toner, CJ van der Linde, Stan Wright.