Ian Costello's Munster 'A' side will launch the defence of their title away to Plymouth Albion on Saturday. In the other Pool 7 tie, Aberavon will welcome Rotherham to the Talbot Athletic Ground.
Munster 'A' became the first Irish province to win the British & Irish Cup with a 31-12 final win over Cross Keys at Musgrave Park last April. Earlier in the knockout stages, they beat both Ulster Ravens (20-9) and Leinster 'A' (36-29).
There are eight Anglo-Welsh ties this weekend, including the meeting of Cardiff and Bristol - the revival of one of the oldest rivalries in club rugby which stretches back 124 years.
Ulster Ravens are in Pool 1 alongside Cardiff and Bristol and will host Welsh side Bridgend in their opener on Saturday afternoon.
Connacht Eagles' debut in the competition will see them battling it out in Pool 4 which contains last year's runners-up Cross Keys, Newcastle Falcons and Newport.
Nigel Carolan's men, who recently claimed back-to-back wins over Munster 'A', will venture to Newport on Saturday for their first game.
Meanwhile, Leinster 'A' will get their campaign underway at home to Leeds Carnegie in Pool 5 on Saturday night. The pool is completed by Jersey and Pontypridd.
The 2012/13 tournament will be played over nine weekends throughout the season, with all of the fixtures taking place on weekend dates. There will be one leg ties for the quarter-finals, semi-finals and final.
BRITISH & IRISH CUP OPENING FIXTURES:
Pool 1 -
Cardiff v Bristol, Saturday, October, 13, 2.30pm
Ulster Ravens v Bridgend, Saturday, October 13, 2.30pm
Pool 2 -
Bedwas v Bedford Blues, Saturday, October 13, 2.30pm
Stirling v Neath, Saturday, October 13, 3pm
Swansea v Dundee, Saturday, October 13, 2.30pm
Cornish Pirates v Carmarthen, Sunday, October 14, 3pm
Pool 4 -
Newport v Connacht Eagles, Saturday, October 13, 2.30pm
Newcastle Falcons v Cross Keys, Saturday, October 13, 3pm
Pool 5 -
Jersey v Pontypridd, Saturday, October 13, 3pm
Leinster 'A' v Leeds Carnegie, Saturday, October 13, 7pm
Pool 6 -
Gala v London Scottish, Saturday, October 13, 3pm
Moseley v Llanelli, Saturday, October 13, 3pm
Pool 7 -
Aberavon v Rotherham Titans, Saturday, October 13, 2.20pm
Plymouth Albion v Munster 'A', Saturday, October 13, 3pm
Pool 8 -
Doncaster Knights v Melrose, Saturday, October 13, 2.30pm
Llandovery v Nottingham, Saturday, October 13, 3pm
2011/12 - Munster 'A'
2010/11 - Bristol
2009/10 - Cornish Pirates