Kevin McLaughlin played the full 80 minutes against Connacht last Saturday, in his first outing for Leinster since last May. He was joined by the returning Eoin O'Malley, who had missed the province's recent victories over Clermont Auvergne and Ulster.
A number of the Ireland internationals who were unavailable for the last two fixtures as part of the IRFU Player Welfare programme - including Gordon D'Arcy, Cian Healy, Jamie Heaslip and Jonathan Sexton - are in contention to play against the Ospreys on Friday.
So too are the likes of Leinster Academy graduates David Kearney, Fergus McFadden and Niall Morris, who were all try scorers in the bonus point victory over Connacht last weekend.
Leinster lie in third place in the Magners League table, a point ahead of the Ospreys, who won the grand final at the RDS last May.
Friday's game marks Leinster's 50th competitive fixture at the RDS and looks set to be played in front of another big crowd.
Ticket sales are fast approaching the 15,000 mark and are available to purchase online here, and from Spar (Donnybrook), the Leinster Rugby Store (Donnybrook), Champion Sports (Grafton Street) as well as Ticketmaster outlets nationwide.