The game may well see the final appearance in a Munster jersey of the province's longest serving players - Anthony Horgan and Frankie Sheahan - as a well as a last showing for Mike Prendergast, Kieran Lewis, Federico Pucciariello, John O'Sullivan and Michael Essex.
When the game ends on Friday night, Munster will be presented with 2008/09 Magners League trophy and officially crowned champions.
MUNSTER Squad (v Ospreys): Backs (11) - Doug Howlett, Barry Murphy, Keith Earls, Ian Dowling, Lifeimi Mafi, Kieran Lewis, Anthony Horgan, Paul Warwick, Ronan O'Gara, Peter Stringer, Mike Prendergast.
Forwards (14) - Federico Pucciariello, Dave Ryan, Denis Fogarty, Mike Essex, Frankie Sheahan, Tony Buckley, Mick O'Driscoll, John O'Sullivan, Donncha O'Callaghan, Paul O'Connell, Donnacha Ryan, David Wallace, Niall Ronan, Denis Leamy.
