Old Wesley ran in four tries as they went to the summit of Division Three on the 2006/07 AIB League's opening afternoon.
The Dubliners, making the first of their five trips to Ulster this season, scored a comprehensive 32-0 win over Portadown at Chambers Park.
Brian Doherty (2), Alan Thompson and Alan Large were all on the scoresheet for Wesley, who ironically lost 29-0 on their only previous visit to Chambers Park in 2005.
Connemara chalked up win number one at Clifden as they saw off City of Derry 18-5. Michael Aspell and Richard Bourke nabbed a try apiece for the Galway men with David Newman kicking a conversion, a penalty and a drop goal. Making use of a strong wind, the hosts led 12-0 at the break.
Other notable results saw league newcomers Rainey Old Boys secure a 17-15 win at Corinthians, while Queen's University and Instonians were both too strong for Waterpark and Bruff.
Former Belfast Harlequins number 10 Michael Glancy kicked two conversions and a penalty as Rainey were victorious in their first ever league game. Darryl Porter and Damien Campbell provided the tries at Hatrick Park.
Queen's had winger Michael Barker and full-back Matt Banks amongst the tries for Queen's in the first half of their 22-7 defeat of Waterpark, while Ulster Under-19 scrum half Ian Porter touched down after the break.
Speaking after the win at the Dub, Queen's director of rugby Robbie Moore said: "Without a doubt we're happy to start with a win, we made it hard work in the second half and I'm disappointed not to have gotten a bonus point.
"The scrum and lineouts were good, the forwards were equal to what the opposition put on us. We defended well especially in the second half when they had the upper hand for a while and the communication between the guys was very good."
Instonians' 23-13 win over Bruff was mainly down to the performance of young out-half Owen McMurray, who scored 13 points - kicking two penalties, two conversions and a drop goal.
Back row Johnny Graham scored the only try at Ballymacarn Park as Ballynahinch held on for an 8-6 triumph over Tipperary visitors Nenagh Ormond.
Sunday's Well came away from Rifle Park with a bonus point after going down 15-10 to Banbridge. Former Ulster, Ireland and Lions winger Tyrone Howe scored one of the hosts' two tries.
Wanderers went fifth in the table thanks to an 11-3 home triumph over Ards. It was the capital side's third win on the trot over the peninsula club - flanker Emmet Wardell scored the game's only try with Wanderers out-half Billy Treacy booting two penalties.
WEEK ONE - AIB LEAGUE DIVISION THREE RESULTS: Ballynahinch 8 Nenagh Ormond 6, Ballymacarn Park; Banbridge 15 Sunday's Well 10, Rifle Park; Connemara 18 City of Derry 5, Monastery Field; Corinthians 15 Rainey Old Boys 17, Corinthian Park; Instonians 23 Bruff 13, Shaws Bridge; Portadown 0 Old Wesley 32, Chambers Park; Queen's University 22 Waterpark 7, Dub Lane; Wanderers 11 Ards 3, Lansdowne Road