Aidan Wynne comes into the side at inside centre for the injured Mel Deane (hamstring) as Connacht and London Irish battle it out for top spot in Pool 1.
Connacht's superb 30-12 away win to Dax in the south of France last week has given Michael Bradley's men a great chance of advancing from the pool.
The first ever competitive fixture between the sides on Friday is poised to go a long way towards deciding the pecking order in this pool. A number of hospitality packages are still available for this historic encounter.
Previewing the game, Bradley said: "It is certainly going to be a big ask for us but, ever since the fixtures were announced, we have been looking forward to what really is a glamour match for us.
"London Irish have a super squad and are a great side - we will be up against the same team who took them all the way to last season's Heineken Cup semi-finals so we are well aware of the challenge they will present.
"They are a pretty formidable club with plenty of pace out wide and power up front and it is going to be a tough gig for us but also one we relish.