The Galway native, a younger brother of former Connacht, Leinster and current Oyonnax second row Damian Browne, came through the Connacht Academy system in 2007 and has enjoyed regular game-time since then, winning 75 PRO12 caps and playing in both the Amlin Challenge Cup and Heineken Cup.
The 26-year-old has played at blindside flanker this season but is equally adept in the second row.
His power and athleticism have made him something of a lineout specialist and he has been an integral part of the Connacht pack featuring in 10 games so far this season.
Browne will join an elite group of Connacht centurions - Michael Swift, John Muldoon, Brett Wilkinson, Gavin Duffy, Ronan Loughney and Frank Murphy - who have all represented Connacht over 100 times and are still playing for the province.
The versatile forward last year signed a new two-year contract to remain at the Sportsground until at least the summer of 2015.
Commenting on the impending milestone, Browne said: "It's a huge, huge honour for me and something you dream of as a young, local lad.
"It would be fantastic to win my 100th cap against Leinster at the weekend and to mark it with a win over the league champions."