That mouthwatering fixture will be followed by the meeting of last season's runners-up Clermont Auvergne and Leicester Tigers at Stade Marcel Michelin.
The Saturday schedule will be completed when number 1 seeds Ulster host Saracens at Ravenhill in a repeat of the 2013 quarter-final won 27-16 by Saracens at Twickenham.
Sunday, April 6 will feature the first match between reigning champions Toulon and three-time winners Leinster at Stade Félix Mayol.
All eight of the Heineken Cup and Amlin Challenge Cup quarter-finals will be televised live with the transmissions going out to up to 150 countries worldwide.
HEINEKEN CUP QUARTER-FINALS:
Saturday, April 5 -
MUNSTER v Toulouse, Thomond Park, 1.30pm (live Sky Sports/Canal +)
Clermont Auvergne v Leicester Tigers, Stade Marcel Michelin, 5pm local time/4pm Irish time (live FR 2/Sky Sports)
ULSTER v Saracens, Ravenhill, 6.30pm (live Sky Sports/Canal +)
Sunday, April 6 -
Toulon v LEINSTER, Stade Félix Mayol, 5.30pm local time/4.30pm Irish time (live FR 2/Sky Sports)
HEINEKEN CUP SEMI-FINALS:
Ulster or Saracens v Clermont Auvergne or Leicester Tigers
Toulon or Leinster v Munster or Toulouse
- Matches to be played on April 25/26/27
FINAL: Saturday, May 24, Millennium Stadium, 5pm