Noel Reid and Darragh Fanning also come into the side, Fanning after playing for the Leinster 'A' team in their fine win over Cross Keys last weekend.
There is a completely new pack selected for the trip to Scotland, with Leo Cullen captaining the side from the second row.
Shane Jennings, who was a late replacement for Sean O'Brien in the Northampton fixture, has retained his place and he is joined in the back row by Kevin McLaughlin and number 8 Jordi Murphy.
LEINSTER (v Edinburgh): Zane Kirchner; Darragh Fanning, Brian O'Driscoll, Noel Reid, Luke Fitzgerald; Ian Madigan, Isaac Boss; Michael Bent, Aaron Dundon, Martin Moore, Leo Cullen (capt), Tom Denton, Kevin McLaughlin, Shane Jennings, Jordi Murphy.
Replacements: James Tracy, Jack O'Connell, Tadhg Furlong, Quinn Roux, Dominic Ryan, John Cooney, Jimmy Gopperth, Brendan Macken.