Sherry, who agreed a new two-year contract last month, starts in the number 2 jersey at Parc y Scarlets. Damien Varley, who has just penned a deal that keeps him at Munster for the next two seasons, was due to provide back-up as the reserve hooker.
But a knee injury has forced Varley out of the matchday squad, with Sean Henry taking his place on the replacements bench.
There are changes aplenty in Rob Penney's starting line-up with Donncha O'Callaghan and Ronan O'Gara, two members of Ireland's RBS 6 Nations squad, both included.
That means a switch to full-back for the in-form Ian Keatley, a position he occupied earlier this season against the Newport Gwent Dragons and Racing Metro 92.
MUNSTER (v Scarlets): Ian Keatley; Denis Hurley, Ivan Dineen, JJ Hanrahan, Johne Murphy; Ronan O'Gara, Duncan Williams; Wian du Preez, Mike Sherry (capt), BJ Botha, Donncha O'Callaghan, Ian Nagle, CJ Stander, Tommy O'Donnell, Paddy Butler.
Replacements: Sean Henry, John Ryan, Stephen Archer, Billy Holland, Sean Dougall, Cathal Sheridan, Danny Barnes, Casey Laulala.