Ireland's most famous rugby family - brothers Richard, Paul and David Wallace - are among those getting back in the saddle after raising €52,000 for the charity during last year's 787km cycle.
Following on from the success of the 2012 event, Paul and the good people at CROSS, whom the former prop is a patron of, have devised a harder and longer route from Malin to Mizen Head into the prevailing winds.
Cyclists can join the legends for any of the one day stages or join them for the full tour and enjoy this amazing trip of a lifetime along the beautiful west coast of Ireland.
David explained: "It all starts next Saturday (September 7) and runs for seven days and my brothers and I along with former internationals, friends, relations and other fellow cyclists of varying degrees of age, fitness and cycling ability will all be taking part to raise money for the charity."
Speaking about where the proceeds go and the week's cycle, Richard said: "The charity is a focal point for cancer research that is undertaken at the Institute of Molecular Medicine located in the Trinity (College) centre at the hospital.
"A significant element of the research programme relates to prevention and treatment of oesophageal and stomach cancer, but the centre also undertakes research in cancer of the breast, colon, rectum and lung.
"We are told that this year's cycle will be about 900km in total but I suspect it will be more like 1000km after we do circuits of town and city centres, evade motorways and speed cameras and divert for sticky buns and ahem, tea!
"We have doubled the numbers this year even though we had wondered if the 'apres cycle' had scared off many of last years heroes!"
Highlighting what a worthy cause it is, Paul added: "CROSS does amazing work in cancer research and very much relies on donated funds. As patron of CROSS, I can guarantee that any donation will be greatly appreciated."
Spaces are filling up fast for the various stages. You can join the cycling group on any of the stages - full details are here - with big southern Hemisphere names such as David Campese and Anton Oliver both signed up to participate.
The Wallace brothers also have their own individual fundraising pages, so please give generously to this very worthy cause:
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