O'Driscoll has particularly fond memories of Paris, thanks to his hat-trick heroics of 2000, but he is determined to make some new memories when these two heavyweights of European rugby collide at the Stade de France.
Then, as a little-known 21-year-old, the Dubliner was catapulted to stardom with a scintillating three-try salvo that underpinned a 27-25 triumph over France.
O'Driscoll said: "My life changed a good bit since then. I didn't realise how big a deal it was until I got home. It was a big change for Irish rugby.
"A lot of new guys had come in during that Six Nations and after winning in Paris, the mentality and focus of the team changed, hopefully for ever.
"If it did anything positive it changed the mentality of us as a rugby team and rugby nation.
"Winning in 2000 was part of the catalyst to how the game for us has changed. It would be silly to say it wasn't.
"We hadn't won in Paris for so long - back in 1972 - and it gave us the belief we could win if we played well."
He added: "There are only three of us remaining from 10 years ago - Rog (Ronan O'Gara), John (Hayes) and myself - so there are a lot of guys who haven't won an international on French soil.
"These are little things that we want to pick off. It would mean a lot to the guys to win on Saturday."