When these teams met at Croke Park last year, it was a hard-fought encounter that eventually went Ireland's way on a 14-13 scoreline.
Team captain Brian O'Driscoll led by example that day with a try and a drop goal, with out-half Ronan O'Gara supplying two penalty goals.
We will have live text commentary direct from Twickenham of Ireland's third match of the 2010 Championship, with lock Donncha O'Callaghan returning from a knee injury and full-back Geordan Murphy and hooker Rory Best replacing the sidelined Rob Kearney (injured) and Jerry Flannery (suspended) respectively.
Out-half Jonathan Sexton is also hoping to flourish on his first RBS 6 Nations start.
Plug in the laptop or turn on the PC and enjoy a flavour of this afternoon's game live on IrishRugby.ie with thanks to O2, sponsors of MatchDay Live.
There will be full live text and score updates throughout the coverage as Ireland look to chalk up their thirteenth Test win in 16 matches under Declan Kidney.
We provide links to the audio match commentary from the RTE Radio 1, BBC Radio Ulster and BBC 5Live teams.
Starting at 3.30pm with our pre-match build-up (the game kicks off at 4pm), you can feel part of the action on IrishRugby.ie with MatchDay Live.
The match is also being broadcast live on RTE Two and BBC One.
Look out for the MatchDay Live button in the RBS 6 Nations and Ireland sections, or simply click on the link below:
O2 MatchDay Live - Click Here